Search results for "interaction [hadron hadron]"
showing 10 items of 212 documents
Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers.
2009
Ligand-mediated dimerization has emerged as a universal mechanism of growth factor receptor activation. Recent structural studies have shown that neurotrophins interact with dimers of the p75 neurotrophin receptor (p75NTR), but the actual mechanism of receptor activation has remained elusive. Here we show that p75NTR forms disulphide-linked dimers independently of neurotrophin binding through the highly conserved Cys257 in its transmembrane domain. Mutation of Cys257 abolished neurotrophin-dependent receptor activity but did not affect downstream signaling by the p75NTR/NgR/Lingo-1 complex in response to MAG, indicating the existence of distinct, ligand-specific activation mechanisms for p7…
Changes in the proteome of sea urchin Paracentrotus lividus coelomocytes in response to LPS injection into the body cavity.
2020
Background The immune system of echinoderm sea urchins is characterised by a high degree of complexity that is not completely understood. The Mediterranean sea urchin Paracentrotus lividus coelomocytes mediate immune responses through phagocytosis, encapsulation of non-self particles, and production of diffusible factors including antimicrobial molecules. Details of these processes, and molecular pathways driving these mechanisms, are still to be fully elucidated. Principal findings In the present study we treated the sea urchin P. lividus with the bacterial lipopolysaccharide (LPS) and collected coelomocytes at different time-points (1, 3, 6 and 24 hours). We have shown, using label-free q…
Effects of Difficulty in Handling Emotions and Social Interactions on Nomophobia: Examining the Mediating Role of Feelings of Loneliness
2022
Abstract This study was addressed to assess nomophobia in an Italian sample (N = 456, 53.1% men, Mage = 31.8, SD = 11.1), also providing a deeper knowledge about how it is distributed across demographics, as well as identifying its best predictors. The main goal was to investigate the direct and indirect effects of difficulty in emotion regulation and social interaction anxiety on nomophobia through loneliness. Our findings indicated that loneliness explained the effect of the expressive suppression strategy (fully) and social interaction anxiety (partially) on nomophobia, whereas it was not a significant mediator when the cognitive reappraisal strategy was taken into account. Our study sug…
Embodied sound design
2018
Abstract Embodied sound design is a process of sound creation that involves the designer’s vocal apparatus and gestures. The possibilities of vocal sketching were investigated by means of an art installation. An artist–designer interpreted several vocal self-portraits and rendered the corresponding synthetic sketches by using physics-based and concatenative sound synthesis. Both synthesis techniques afforded a broad range of artificial sound objects, from concrete to abstract, all derived from natural vocalisations. The vocal-to-synthetic transformation process was then automated in SEeD, a tool allowing to set and play interactively with physics- or corpus-based sound models. The voice-dri…
Children’s conceptions of mental well-being and ideas for its promotion through digital environments
2021
The aim of this study is to further understanding of children’s conceptions of mental well-being and their ideas for its digital promotion. The study is based on the need to provide children an opportunity to actively participate and share their understanding of mental well-being promotion with others in light of their understanding of what online environments and their design can afford for this promotion. The study was implemented as three subsequent workshops in primary school classrooms comprising four teachers and 79 children aged 9-11 years old. In the first two workshops, children reflected on mental well-being, digital environments they utilise and their possible connections to ment…
Phosphorylation of the Usher syndrome 1G protein SANS controls Magi2-mediated endocytosis.
2014
Item does not contain fulltext The human Usher syndrome (USH) is a complex ciliopathy with at least 12 chromosomal loci assigned to three clinical subtypes, USH1-3. The heterogeneous USH proteins are organized into protein networks. Here, we identified Magi2 (membrane-associated guanylate kinase inverted-2) as a new component of the USH protein interactome, binding to the multifunctional scaffold protein SANS (USH1G). We showed that the SANS-Magi2 complex assembly is regulated by the phosphorylation of an internal PDZ-binding motif in the sterile alpha motif domain of SANS by the protein kinase CK2. We affirmed Magi2's role in receptor-mediated, clathrin-dependent endocytosis and showed tha…
Life-based design as an extension of problem-based learning — A tool for understanding people and technology
2015
Global conditions are changing at such a rate that foreseeing trends in technological development, economic fluctuations and climatic conditions is ever more difficult. When developing technologies, there is one constant factor that practitioners and researchers should be aware of, and that is people. This is not to say that people, culture and social conditions remain stagnant, for these too evolve with the surrounding circumstances. Rather, appropriate tools and capabilities for investigating people, their lives and life situations, are integral to understanding what people need in terms of technology, how these technologies will be used, and more importantly how they will be valued in th…
SYMBOLIC INTERACTIONS:TOWARDS A COGNITIVE SCIENTIFIC THEORY OF MEANING IN HUMAN TECHNOLOGY INTERACTION
2015
Information technology has perpetuated the role of symbolism in everyday life practice, through its reliance on sign systems for its creation and operation. Increasingly attention has been placed on applying semiotic techniques to analyze user interface design and usability. Surprisingly, although the move towards symbolic interaction has been one of the most striking components of the digital shift, it has proven difficult to build bridges between semiotics and HTI-design thinking. In this article we argue that the problems in linking semiotic analysis of human technology interaction with modern HTI-design paradigms such as usability or user experience arise from a theoretical gap between …
Siti Web Museali: Identità Perdute. Appunti per una “storia” del progetto web museale nei primi anni 2000
2021
This discussion tries to investigate the theme of the "web amnesia" in relation to the website project of cultural institutions. More precisely, the reflection is inspired by a "rereading" of a research experience gained within the University of Palermo through the drafting of a doctoral thesis entitled "The web for culture. From digital identity to the design of online services” which had as its objective the mapping of the websites of museums or cultural institutions in relation to quality criteria, operational indications, design guidelines and, in general, to all the issues of the sectoral scientific debate of the early 2000s. Today, thanks to this possible reinterpretation, this resear…
I musei minerari: percorsi del museo delle Solfare di Trabia-Tallarita
2013
L’area dell’ex miniera di zolfo Trabia-Tallarita, si trova nel cuore della Sicilia, in provincia di Caltanissetta. È una zona depositaria di una storia multiforme e sfaccettata, la storia di un peculiare sviluppo industriale e commerciale. Si tratta della storia di un’evoluzione scientifica e tecnologica, di uomini e famiglie, di un’intera società che ruota e cambia intorno alla miniera. L’allestimento, progettato da Michele Pedrazzi (interaction designer) e realizzato dall’Asteria Multimedia di Trento, raccoglie tutti questi fili attraverso esperienze visive e sensoriali, come la simulazione della discesa in galleria, la stanza immersiva con proiezione a 360° e i diversi tavoli da lavoro i…